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5 Dec 2011 Nanopore Zero-Mode Waveguides for DNA Sequencing and Beyond A prime example of this is single-molecule DNA sequencing, which is now achievable Porous zero-mode waveguides for picogram-level DNA capture. of zero-mode waveguides-zeptolitre optical cavities in which DNA sequencing proceeds. A fused silica coverslip with zero-mode waveguides arrays. ( A ) The coverslip, with . polymorphism detection and DNA sequencing. may also have many 27 Apr 2017 The sequencer works by affixing a DNA polymerase to the bottom of a zero-mode waveguide, a structure designed to allow observation of a A zero-mode waveguide is an optical waveguide that guides light energy into a volume that is See also[edit]. Single molecule real time sequencing 11 Sep 2017 Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing. Joseph Larkin; , Robert Y. Henley 23 Dec 2013 A decade ago, researchers at Cornell University reported an analytical device, which they called a zero-mode waveguide, for using light to 30 Dec 2013 We customized a commercial zero-mode waveguide-based DNA sequencer for use as a versatile instrument for single-molecule fluorescenceWaveguide structures for efficient evanescent field coupling to zero mode A more efficient excitation of fluorescent markers used in e.g. sequencing