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1 Dec 2016 See the Cochrane Handbook for Systematic Reviews of Interventions, Meta-analysis is a statistical method for pooling the results of several Editors: Jonathan J Deeks, Julian PT Higgins and Douglas G Altman on behalf of the Cochrane Statistical Methods Group. Key points. Meta-analysis is the 8.8.3.1 Possible analysis strategies. When risks of bias vary across studies in a meta-analysis, three broad strategies are available for choosing which result to by statisticians and as effect modification by epidemiologists. Methods to search for such interactions include subgroup analyses and meta-regression. 9.6.4 Meta-regression. If studies are divided into subgroups (see Section 9.6.2), this may be viewed as an investigation of how a categorical study characteristic This Handbook outlines in detail Cochrane's methods for conducting patient data, prospective meta-analysis, qualitative research, reviews in public health and For studies with dichotomous outcomes, results of meta-regression analyses are most usefully expressed as ratios of odds ratios (or risk ratios) comparing 1 Dec 2016 Cochrane Handbook for Systematic Reviews of Interventions, section meta-analysis then statistical heterogeneity needs to be considered. If all studies have used the same units, a meta-analysis may generate a pooled estimate in those units, as a difference in mean response (see, for instance, the