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Clostridioides difficile infection (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium, Clostridioides difficile. Symptoms include watery diarrhea, fever, nausea, and abdominal pain. It makes up about 20% of cases of antibiotic-associated diarrhea. Centers for Disease Control and Prevention. Clostridium difficile infection Accessed 1/3/2017. American College of Gastroenterology. Guidelines for Diagnosis, Treatment and Prevention of Clostridium difficile Infections Accessed 1/3/2017. The Merck Manual for Health Care Professionals. Clostridium difficile-Induced Diarrhea Accessed 1/3/2017. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Surawicz CM(1), Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, McFarland LV, Mellow M, Zuckerbraun BS. Clostridium difficile infection (CDI) is a leading cause of hospital-associated American College of Gastroenterology Releases C. Diff and infection control and prevention. 2 Previous recommendations for the prevention, diagnosis, and treatment of CDI have been provided by the European et al. Guidelines for diagnosis, treatment and prevention of Clostridium difficile Table 1. CDI Treatment Guidelines for SHC Indexed by Severity Guidelines for the treatment of Clostridium difficile infection (CDI) were first produced by the Stanford C. Stage of Disease: After the diagnosis is made, it is important to stage the disease to guide treatment by both Appropriate diagnosis, treatment and prevention of Clostridium difficile. It has become evident that surgery is of benefit to patients at the advanced extreme of C. difficile infection (CDI), and early surgical consultation has been associated with improved survival. More recently, FDA approved in 2017 bezlotoxumab, a human monoclonal antibody that binds to and neutralizes C. difficile toxin B, to prevent CDI recurrence in adults receiving antibiotic
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