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PRINCIPLES OF IMMUNOLOGY Cell-Mediated Immunity There are three (3) major exams plus the final exam planned for this course. At the. The activation of T cells is an essential first stage in virtually all adaptive immune responses. This is called the “T cell-dependent immune response”. T cells2. Outline the basic principles of immune responses and the timescales in which they occur. IFN: Interferon (innate immunity). NK: